Cytotoxicity and genotoxicity of coronaridine from Tabernaemontana catharinensis A.DC in a human laryngeal epithelial carcinoma cell line (Hep-2)
Identifieur interne : 000276 ( Main/Exploration ); précédent : 000275; suivant : 000277Cytotoxicity and genotoxicity of coronaridine from Tabernaemontana catharinensis A.DC in a human laryngeal epithelial carcinoma cell line (Hep-2)
Auteurs : Walace Fraga Rizo [Brésil] ; Luis Eduardo Ferreira [Brésil] ; Vanessa Colnaghi [Brésil] ; Juliana Sim Es Martins [Brésil] ; Leonardo Pereira Franchi [Brésil] ; Catarina Satie Takahashi [Brésil] ; Rene Oliveira Beleboni [Brésil] ; Mozart Marins [Brésil] ; Paulo Sérgio Pereira [Brésil] ; Ana Lúcia Fachin [Brésil]Source :
- Genetics and Molecular Biology [ 1415-4757 ] ; 2013.
Abstract
Cancer has become a major public health problem worldwide and the number of deaths due to this disease is increasing almost exponentially. In the constant search for new treatments, natural products of plant origin have provided a variety of new compounds to be explored as antitumor agents.
Url:
DOI: 10.1590/S1415-47572013005000010
PubMed: 23569415
PubMed Central: 3615513
Affiliations:
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Biotecnologia Vegetal, Universidade de Ribeirão Preto, Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Ferreira, Luis Eduardo" sort="Ferreira, Luis Eduardo" uniqKey="Ferreira L" first="Luis Eduardo" last="Ferreira">Luis Eduardo Ferreira</name><affiliation wicri:level="2"><nlm:aff id="af1-gmb-36-105">Unidade de Biotecnologia Vegetal, Universidade de Ribeirão Preto, Ribeirão Preto, SP, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Unidade de Biotecnologia Vegetal, Universidade de Ribeirão Preto, Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Colnaghi, Vanessa" sort="Colnaghi, Vanessa" uniqKey="Colnaghi V" first="Vanessa" last="Colnaghi">Vanessa Colnaghi</name><affiliation wicri:level="2"><nlm:aff id="af1-gmb-36-105">Unidade de Biotecnologia Vegetal, Universidade de Ribeirão Preto, Ribeirão Preto, SP, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Unidade de Biotecnologia Vegetal, Universidade de Ribeirão Preto, Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Martins, Juliana Sim Es" sort="Martins, Juliana Sim Es" uniqKey="Martins J" first="Juliana Sim Es" last="Martins">Juliana Sim Es Martins</name><affiliation wicri:level="2"><nlm:aff id="af1-gmb-36-105">Unidade de Biotecnologia Vegetal, Universidade de Ribeirão Preto, Ribeirão Preto, SP, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Unidade de Biotecnologia Vegetal, Universidade de Ribeirão Preto, Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Franchi, Leonardo Pereira" sort="Franchi, Leonardo Pereira" uniqKey="Franchi L" first="Leonardo Pereira" last="Franchi">Leonardo Pereira Franchi</name><affiliation wicri:level="4"><nlm:aff id="af2-gmb-36-105">Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Takahashi, Catarina Satie" sort="Takahashi, Catarina Satie" uniqKey="Takahashi C" first="Catarina Satie" last="Takahashi">Catarina Satie Takahashi</name><affiliation wicri:level="4"><nlm:aff id="af2-gmb-36-105">Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Beleboni, Rene Oliveira" sort="Beleboni, Rene Oliveira" uniqKey="Beleboni R" first="Rene Oliveira" last="Beleboni">Rene Oliveira Beleboni</name><affiliation wicri:level="2"><nlm:aff id="af1-gmb-36-105">Unidade de Biotecnologia Vegetal, Universidade de Ribeirão Preto, Ribeirão Preto, SP, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Unidade de Biotecnologia Vegetal, Universidade de Ribeirão Preto, Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Marins, Mozart" sort="Marins, Mozart" uniqKey="Marins M" first="Mozart" last="Marins">Mozart Marins</name><affiliation wicri:level="2"><nlm:aff id="af1-gmb-36-105">Unidade de Biotecnologia Vegetal, Universidade de Ribeirão Preto, Ribeirão Preto, SP, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Unidade de Biotecnologia Vegetal, Universidade de Ribeirão Preto, Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Pereira, Paulo Sergio" sort="Pereira, Paulo Sergio" uniqKey="Pereira P" first="Paulo Sérgio" last="Pereira">Paulo Sérgio Pereira</name><affiliation wicri:level="2"><nlm:aff id="af1-gmb-36-105">Unidade de Biotecnologia Vegetal, Universidade de Ribeirão Preto, Ribeirão Preto, SP, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Unidade de Biotecnologia Vegetal, Universidade de Ribeirão Preto, Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Fachin, Ana Lucia" sort="Fachin, Ana Lucia" uniqKey="Fachin A" first="Ana Lúcia" last="Fachin">Ana Lúcia Fachin</name><affiliation wicri:level="2"><nlm:aff id="af1-gmb-36-105">Unidade de Biotecnologia Vegetal, Universidade de Ribeirão Preto, Ribeirão Preto, SP, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Unidade de Biotecnologia Vegetal, Universidade de Ribeirão Preto, Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author></analytic><series><title level="j">Genetics and Molecular Biology</title><idno type="ISSN">1415-4757</idno><idno type="e-ISSN">1678-4685</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Cancer has become a major public health problem worldwide and the number of deaths due to this disease is increasing almost exponentially. In the constant search for new treatments, natural products of plant origin have provided a variety of new compounds to be explored as antitumor agents. <italic>Tabernaemontana catharinensis</italic> is a medicinal plant that produces alkaloids with expressive antitumor activity, such as heyneanine, coronaridine and voacangine. The aim of present study was firstly to screen the cytotoxic activity of the indole alkaloids heyneanine, coronaridine and voacangine against HeLa (human cervix tumor), 3T3 (normal mouse embryo fibroblasts), Hep-2 (human laryngeal epithelial carcinoma) and B-16 (murine skin) cell lines by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide); and secondly to analyze the apoptotic activity, cell membrane damage and genotoxicity of the compound that showed the best cytotoxic activity against the tumor cell lines tested. Coronaridine was the one that exhibited greater cytotoxic activity in the laryngeal carcinoma cell line Hep-2 (IC<sub>50</sub> = 54.47 μg/mL) than the other alkaloids tested (voacangine IC<sub>50</sub> = 159.33 g/mL, and heyneanine IC<sub>50</sub> = 689.45 μg/mL). Coronaridine induced apoptosis in cell lines 3T3 and Hep-2, even at high concentrations. The evaluation of genotoxicity by comet assay showed further that coronaridine caused minimal DNA damage in the Hep-2 tumor cell line, and the LDH test showed that it did not affect the plasma membrane. These results suggest that further investigation of coronaridine as an antitumor agent has merit.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Andrade, Mt" uniqKey="Andrade M">MT Andrade</name></author><author><name sortKey="Lima, Ja" uniqKey="Lima J">JA Lima</name></author><author><name sortKey="Pinto, Ac" uniqKey="Pinto A">AC Pinto</name></author><author><name sortKey="Rezende, Cm" uniqKey="Rezende C">CM Rezende</name></author><author><name sortKey="Carvalho, Mp" uniqKey="Carvalho M">MP Carvalho</name></author><author><name sortKey="Epifanio, Ra" uniqKey="Epifanio R">RA Epifanio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Araujo, Cc" uniqKey="Araujo C">CC Araujo</name></author><author><name sortKey="Leon, Ll" uniqKey="Leon L">LL Leon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bradacs, G" uniqKey="Bradacs G">G Bradacs</name></author><author><name 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Fraga" sort="Rizo, Walace Fraga" uniqKey="Rizo W" first="Walace Fraga" last="Rizo">Walace Fraga Rizo</name></region><name sortKey="Beleboni, Rene Oliveira" sort="Beleboni, Rene Oliveira" uniqKey="Beleboni R" first="Rene Oliveira" last="Beleboni">Rene Oliveira Beleboni</name><name sortKey="Colnaghi, Vanessa" sort="Colnaghi, Vanessa" uniqKey="Colnaghi V" first="Vanessa" last="Colnaghi">Vanessa Colnaghi</name><name sortKey="Fachin, Ana Lucia" sort="Fachin, Ana Lucia" uniqKey="Fachin A" first="Ana Lúcia" last="Fachin">Ana Lúcia Fachin</name><name sortKey="Ferreira, Luis Eduardo" sort="Ferreira, Luis Eduardo" uniqKey="Ferreira L" first="Luis Eduardo" last="Ferreira">Luis Eduardo Ferreira</name><name sortKey="Franchi, Leonardo Pereira" sort="Franchi, Leonardo Pereira" uniqKey="Franchi L" first="Leonardo Pereira" last="Franchi">Leonardo Pereira Franchi</name><name sortKey="Marins, Mozart" sort="Marins, Mozart" uniqKey="Marins M" first="Mozart" last="Marins">Mozart Marins</name><name sortKey="Martins, Juliana Sim Es" sort="Martins, Juliana Sim Es" uniqKey="Martins J" first="Juliana Sim Es" last="Martins">Juliana Sim Es Martins</name><name sortKey="Pereira, Paulo Sergio" sort="Pereira, Paulo Sergio" uniqKey="Pereira P" first="Paulo Sérgio" last="Pereira">Paulo Sérgio Pereira</name><name sortKey="Takahashi, Catarina Satie" sort="Takahashi, Catarina Satie" uniqKey="Takahashi C" first="Catarina Satie" last="Takahashi">Catarina Satie Takahashi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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